Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701305 | 0.93 | NPC1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6690576 | 0.87 | NPC1 (0.41) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6689396 | 0.86 | NPC1 (0.41) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6670100 | 0.80 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6086055 | 0.79 | CEPT1 (0.39) | NPC1RAB9AMAPTSMN1; SMN2FASN | |
| SCHEMBL6686207 | 0.79 | NAMPT (0.48) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6694405 | 0.78 | SMN1; SMN2 (0.45) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6084633 | 0.77 | CETP (0.46) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6085522 | 0.75 | NPC1 (0.41) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6085861 | 0.74 | NPC1 (0.52) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002062804-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2002-08-15 | — | — | WO | disclosed |