Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842712 | 0.94 | FLT1 (0.41) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6842638 | 0.92 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6659876 | 0.87 | SMN1; SMN2 (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6658375 | 0.87 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6678922 | 0.87 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6689185 | 0.86 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6683886 | 0.86 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6661177 | 0.86 | CCR5 (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6844123 | 0.86 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6654648 | 0.84 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076669-A2 | CYSTEINE-SUBSTITUTED, FAD-DEPENDENT SULFHYDRYL OXIDASES | HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF (DE) | 2004-09-10 | — | — | WO | disclosed |
| EP-1435958-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032993-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |