Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11412911 | 0.80 | KMT2A (0.49) | SLC6A4SLC6A2NOTUMKMT2ATSHR | |
| SCHEMBL526316 | 0.77 | NOTUM (0.49) | SLC6A4SLC6A2NOTUMKMT2ATSHR | |
| SCHEMBL18685611 | 0.77 | SLC6A4 (0.59) | SLC6A4SLC6A2 | |
| SCHEMBL2886772 | 0.76 | SLC6A4 (0.54) | SLC6A4SLC6A2 | |
| SCHEMBL2283629 | 0.75 | KMT2A (0.47) | SLC6A4SLC6A2NOTUMKMT2ATSHR | |
| SCHEMBL9337141 | 0.75 | KMT2A (0.44) | SLC6A4SLC6A2NOTUMKMT2ATSHR | |
| SCHEMBL6987811 | 0.74 | MAPT (0.45) | KMT2ATSHRL3MBTL1LMNAGAA | |
| SCHEMBL11307747 | 0.73 | NR3C2 (0.75) | SLC6A4SLC6A2NOTUMNR3C2 | |
| SCHEMBL30952648 | 0.73 | KMT2A (0.50) | SLC6A4SLC6A2NOTUMKMT2ATSHR | |
| SCHEMBL1967791 | 0.73 | SLC6A4 (0.47) | SLC6A4SLC6A2NOTUMKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324985-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1324985-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028831-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-04-11 | — | — | WO | disclosed |