Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 13/20 | 0.71 |
| ▸ | F3 | P13726 | 10/20 | 0.71 |
| ▸ | F2 | P00734 | 8/20 | 0.61 |
| ▸ | F10 | P00742 | 8/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.61 |
| ▸ | HPN | P05981 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 7/20 | 0.50 |
| ▸ | PLAU | P00749 | 7/20 | 0.50 |
| ▸ | PLAT | P00750 | 6/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691777 | 0.91 | F7 (0.71) | F7F3F2F10PRSS1 | |
| SCHEMBL6690412 | 0.83 | F7 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL6293507 | 0.82 | F7 (0.76) | F7F3F2F10PRSS1 | |
| SCHEMBL6690705 | 0.79 | F7 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL6687000 | 0.79 | F7 (0.55) | F7F3F2F10PRSS1 | |
| SCHEMBL6289508 | 0.77 | HPN (0.63) | F7F2F10PRSS1PRSS2 | |
| SCHEMBL6689788 | 0.75 | F7 (0.63) | F7F3F2F10PRSS1 | |
| SCHEMBL6393251 | 0.75 | HPN (0.56) | F7F3F2F10PRSS1 | |
| SCHEMBL6394658 | 0.75 | HPN (0.56) | F7F3F2F10PRSS1 | |
| SCHEMBL6292953 | 0.75 | F2 (0.70) | F7F3F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004062661-A1 | 2-‘5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |