Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 14/20 | 1.00 |
| ▸ | F3 | P13726 | 11/20 | 1.00 |
| ▸ | F2 | P00734 | 7/20 | 0.77 |
| ▸ | F10 | P00742 | 6/20 | 0.77 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.77 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.77 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.77 |
| ▸ | PLG | P00747 | 5/20 | 0.72 |
| ▸ | PLAU | P00749 | 5/20 | 0.72 |
| ▸ | PLAT | P00750 | 5/20 | 0.72 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.69 |
| ▸ | HPN | P05981 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690705 | 0.91 | F7 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL6293507 | 0.86 | F7 (0.76) | F7F3F2F10PRSS1 | |
| SCHEMBL6292958 | 0.84 | F2 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL6427056 | 0.83 | F7 (0.79) | F7F3F2F10PRSS1 | |
| SCHEMBL6689911 | 0.83 | F7 (0.71) | F7F3F2F10PRSS1 | |
| SCHEMBL6691777 | 0.83 | F7 (0.71) | F7F3F2F10PRSS1 | |
| SCHEMBL29682938 | 0.82 | F2 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL1325070 | 0.82 | F2 (1.00) | F7F3F2F10PRSS1 | |
| SCHEMBL6689506 | 0.82 | F7 (0.73) | F7F3F2F10PRSS1 | |
| SCHEMBL23752572 | 0.81 | F2 (0.78) | F7F3F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004062661-A1 | 2-‘5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | claimed |
| WO-2004062661-A1 | 2-‘5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |