Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.56 |
| ▸ | PDE4A | P27815 | 6/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694346 | 0.91 | PDE4A (0.66) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6694212 | 0.86 | TNF (0.69) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6690149 | 0.81 | TNF (0.59) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6098458 | 0.80 | PDE4A (0.84) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12310209 | 0.76 | CYSLTR2 (0.49) | LMNAKMT2ACYSLTR2CYSLTR1ALDH1A1 | |
| SCHEMBL6688750 | 0.75 | PDE4A (0.68) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6693294 | 0.75 | CYSLTR2 (0.48) | LMNAKMT2ACYSLTR2CYSLTR1ALDH1A1 | |
| SCHEMBL6692793 | 0.75 | PDE4A (0.89) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6692796 | 0.74 | TNF (0.80) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8007597 | 0.74 | PDE4A (0.82) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1004572-A2 | Amines as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004580-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004581-A2 | Process for the preparation of thalidomide | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5605914-A | INHIBITORS OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |