Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.82 |
| ▸ | TNF | P01375 | 10/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692796 | 0.96 | TNF (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6098458 | 0.95 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7748778 | 0.91 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6098481 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL3120500 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL3121844 | 0.89 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6691297 | 0.89 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6690004 | 0.89 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6688721 | 0.89 | TNF (0.82) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6692793 | 0.85 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |