Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 16/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.43 |
| ▸ | CDK4 | P11802 | 10/20 | 0.43 |
| ▸ | CCND1 | P24385 | 10/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.42 |
| ▸ | CDK1 | P06493 | 8/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.42 |
| ▸ | CCND2 | P30279 | 2/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | CASK | O14936 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693000 | 0.99 | CDK2 (0.44) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6690198 | 0.84 | CDK2 (0.57) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6693006 | 0.83 | CDK2 (0.58) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6691889 | 0.77 | CDK2 (0.47) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL14714709 | 0.76 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6692083 | 0.75 | CDK2 (0.70) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6689476 | 0.73 | CDK2 (0.74) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL5875892 | 0.67 | HSD17B10 (0.39) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL15538021 | 0.62 | CCNE1 (0.41) | CDK2CCNE1CDK9CDK8CDK5 | |
| SCHEMBL3340646 | 0.61 | MEN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113353-A1 | SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS | AMEDIS PHARMACEUTICALS LTD. (GB) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113353-A1 | SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS | AMEDIS PHARMACEUTICALS LTD. (GB) | 2004-12-29 | — | — | WO | disclosed |