Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 15/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.47 |
| ▸ | CDK4 | P11802 | 10/20 | 0.47 |
| ▸ | CCND1 | P24385 | 10/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 7/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.46 |
| ▸ | CCND3 | P30281 | 4/20 | 0.46 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14714709 | 0.83 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6691895 | 0.81 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6695938 | 0.79 | CCNE2 (0.76) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6249266 | 0.77 | AOC3 (0.33) | — | |
| SCHEMBL6690193 | 0.77 | CDK2 (0.43) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL5875892 | 0.74 | HSD17B10 (0.39) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6693212 | 0.72 | CDK2 (0.74) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6695162 | 0.71 | CDK2 (0.77) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6694359 | 0.70 | CDK2 (0.78) | CDK2CCNE2CCNE1CDK4CCND1 | |
| SCHEMBL6691176 | 0.70 | CDK2 (0.78) | CDK2CCNE2CCNE1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113353-A1 | SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS | AMEDIS PHARMACEUTICALS LTD. (GB) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113353-A1 | SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS | AMEDIS PHARMACEUTICALS LTD. (GB) | 2004-12-29 | — | — | WO | disclosed |