Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026191 | 0.94 | ADORA2A (0.40) | ERCC1FEN1ERCC4ADORA2AADORA2B | |
| SCHEMBL6690248 | 0.93 | ADORA2A (0.40) | ERCC1FEN1ERCC4ADORA2AADORA2B | |
| SCHEMBL4030768 | 0.83 | ERCC1 (0.57) | ERCC1FEN1ERCC4ADORA2BGAA | |
| SCHEMBL13824026 | 0.79 | ADORA2A (0.45) | ADORA2AADORA2BGAAKDM4EALDH1A1 | |
| SCHEMBL22078872 | 0.78 | ERCC1 (0.56) | ERCC1FEN1ERCC4ADORA2AADORA2B | |
| SCHEMBL4028967 | 0.78 | SMPD1 (0.46) | COMTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13823925 | 0.75 | NPC1 (0.42) | GAAKDM4EALDH1A1GABRG2GABRB3 | |
| SCHEMBL22078880 | 0.73 | ELANE (0.43) | ERCC1FEN1ERCC4ADORA2AADORA2B | |
| SCHEMBL31365367 | 0.73 | ELANE (0.43) | ERCC1FEN1ERCC4ADORA2AADORA2B | |
| SCHEMBL4026627 | 0.73 | ERCC1 (0.56) | ERCC1FEN1ERCC4GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062211-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-07-31 | — | — | WO | disclosed |