Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22078880 | 1.00 | ELANE (0.43) | ELANEERCC1FEN1ERCC4TSHR | |
| SCHEMBL22078875 | 0.86 | GABRA2 (0.46) | ERCC1FEN1ERCC4NPSR1MAPT | |
| SCHEMBL22078872 | 0.86 | ERCC1 (0.56) | ERCC1FEN1ERCC4MAPTADORA2A | |
| SCHEMBL22078792 | 0.84 | ADORA2A (0.38) | ELANEERCC1FEN1ERCC4ADORA2A | |
| SCHEMBL14173477 | 0.81 | ADORA2A (0.48) | ERCC1FEN1ERCC4NPSR1MAPT | |
| SCHEMBL22079304 | 0.79 | ERCC1 (0.41) | ERCC1FEN1ERCC4TSHRMAPT | |
| SCHEMBL31365376 | 0.78 | ERCC1 (0.43) | ERCC1FEN1ERCC4TSHRMAPT | |
| SCHEMBL22078879 | 0.78 | ERCC1 (0.43) | ERCC1FEN1ERCC4TSHRMAPT | |
| SCHEMBL22079746 | 0.77 | KMT2A (0.36) | ERCC1FEN1ERCC4MAPTCOMT | |
| SCHEMBL31365365 | 0.77 | KMT2A (0.36) | ERCC1FEN1ERCC4MAPTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136588-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2025-05-01 | — | — | US | disclosed |
| US-12172990-B2 | Modulators of TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2024-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136588-A1 | MODULATORS OF TREX1 | TSNAX, TEAD1, TMX1 | ELANE 1083/4885ERCC1 1861/4885FEN1 307/4885 |
| US-12172990-B2 | Modulators of TREX1 | CFTR, SLC10A1, CYP27A1 | ELANE 958/4885ERCC1 521/4885FEN1 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.