Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 7-Desethyl-Norfloxacin SCHEMBL5551203 | 0.92 | TOP1 (0.70) | TOP1HPGDLMNAPOLBTAAR1 | |
| 7-Desethyl-Norfloxacin SCHEMBL30610053 | 0.92 | TOP1 (0.70) | TOP1HPGDLMNAPOLBTAAR1 | |
| 7-Desethyl-Norfloxacin SCHEMBL29548802 | 0.91 | TOP1 (0.68) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL28334702 | 0.89 | HPGD (0.62) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL22698659 | 0.86 | HPGD (0.65) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL15281991 | 0.83 | TOP1 (0.67) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL5549146 | 0.82 | KDM4E (0.56) | TOP1HPGDLMNAKDM4EALDH1A1 | |
| SCHEMBL3812477 | 0.82 | HPGD (0.56) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL16591582 | 0.81 | HPGD (0.55) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL501895 | 0.81 | DRD3 (0.68) | HPGDLMNAPOLBTAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004101584-A1 | MACROLIDES SUBSTITUTED AT THE 3-POSITION HAVING ANTIMICROBIAL ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |