Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809881 | 0.92 | DPP4 (0.52) | DPP4AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL6809878 | 0.92 | DPP4 (0.52) | DPP4AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL22501529 | 0.85 | EPHX1 (0.45) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL12463556 | 0.85 | EPHX1 (0.45) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL24425262 | 0.85 | HDAC4 (0.41) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL9099994 | 0.84 | AAK1 (0.40) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL9099990 | 0.84 | AAK1 (0.40) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL6698692 | 0.83 | DPP4 (0.51) | DPP4AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL6698698 | 0.83 | DPP4 (0.51) | DPP4AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL6813595 | 0.82 | EPHX1 (0.43) | DPP4AAK1HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004071454-A2 | SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-08-26 | — | — | WO | disclosed |