Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 11/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693115 | 0.87 | FABP3 (0.45) | FABP3FABP4HDAC1HDAC6POLB | |
| SCHEMBL6774729 | 0.86 | HDAC1 (0.45) | FABP4HDAC1HDAC6P2RX7TSHR | |
| SCHEMBL6689321 | 0.86 | HDAC1 (0.42) | FABP4C5AR1HDAC1HDAC6KDM4E | |
| SCHEMBL6694051 | 0.85 | HDAC1 (0.44) | HDAC1HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL6771495 | 0.85 | C5AR1 (0.40) | FABP3FABP4C5AR1P2RX7KIF11 | |
| SCHEMBL6693351 | 0.85 | HDAC1 (0.39) | FABP3FABP4HDAC1HDAC6P2RX7 | |
| SCHEMBL6691242 | 0.85 | HDAC1 (0.46) | FABP4HDAC1HDAC6P2RX7KDM4E | |
| SCHEMBL5207833 | 0.84 | HDAC1 (0.51) | FABP3FABP4HDAC1HDAC6KDM4E | |
| SCHEMBL6688522 | 0.84 | HDAC1 (0.43) | FABP4HDAC1HDAC6TSHRTDP1 | |
| SCHEMBL6775399 | 0.84 | PLA2G2A (0.42) | FABP4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |