Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | HPD | P32754 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694057 | 0.93 | MAPT (0.45) | HDAC1HDAC6GAANPSR1L3MBTL1 | |
| SCHEMBL5207833 | 0.89 | HDAC1 (0.51) | HDAC1HDAC6SMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL6693631 | 0.86 | HDAC1 (0.45) | HDAC1HDAC6MAPTSMN1; SMN2P2RX7 | |
| SCHEMBL6693334 | 0.86 | HDAC1 (0.43) | HDAC1HDAC6MAPTP2RX7PTGS1 | |
| SCHEMBL6691868 | 0.86 | HDAC1 (0.47) | HDAC1HDAC6GAAL3MBTL1MAPT | |
| SCHEMBL6773523 | 0.86 | HDAC1 (0.47) | HDAC1HDAC6P2RX7PTGS1PTGS2 | |
| SCHEMBL6782203 | 0.86 | HDAC1 (0.45) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6780169 | 0.85 | HDAC1 (0.44) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6775629 | 0.85 | HDAC1 (0.44) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6689321 | 0.85 | HDAC1 (0.42) | HDAC1HDAC6GAANPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |