Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694057 | 0.89 | MAPT (0.45) | HDAC1HDAC6MAPK8CSNK2A2CSNK2B | |
| SCHEMBL5207833 | 0.89 | HDAC1 (0.51) | HDAC1HDAC6MAPK8CSNK2A2CSNK2B | |
| SCHEMBL6693334 | 0.89 | HDAC1 (0.43) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6691868 | 0.89 | HDAC1 (0.47) | HDAC1HDAC6P2RX7PDE3BPDE3A | |
| SCHEMBL6693631 | 0.89 | HDAC1 (0.45) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6775629 | 0.88 | HDAC1 (0.44) | HDAC1HDAC6P2RX7MAPK8CSNK2A2 | |
| SCHEMBL6780169 | 0.88 | HDAC1 (0.44) | HDAC1HDAC6P2RX7PDE3BPDE3A | |
| SCHEMBL6773523 | 0.86 | HDAC1 (0.47) | HDAC1HDAC6P2RX7CSNK2A2CSNK2B | |
| SCHEMBL6691809 | 0.86 | HDAC1 (0.44) | HDAC1HDAC6P2RX7HPDCSNK2A2 | |
| SCHEMBL6691715 | 0.86 | FABP4 (0.47) | HDAC1HDAC6FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |