Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.64 |
| ▸ | ABL1 | P00519 | 5/20 | 0.64 |
| ▸ | BCR | P11274 | 4/20 | 0.64 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.58 |
| ▸ | WEE1 | P30291 | 2/20 | 0.58 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.58 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | CASK | O14936 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687212 | 0.90 | SRC (0.73) | SRCABL1BCRFYNEGFR | |
| SCHEMBL6688427 | 0.88 | SRC (0.58) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL6687249 | 0.88 | SRC (0.58) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL3678116 | 0.81 | WEE2 (0.69) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL6704646 | 0.81 | SRC (0.66) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL5723443 | 0.79 | SRC (0.67) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL5466475 | 0.78 | SRC (0.67) | SRCABL1BCRFYNEGFR | |
| SCHEMBL3193552 | 0.78 | SRC (0.61) | SRCPKMYT1EGFRRETEPHA2 | |
| SCHEMBL4492578 | 0.78 | SRC (0.60) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL6687060 | 0.78 | SRC (0.70) | SRCABL1BCRFYNEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069249-A1 | 3-CYANO-QUINOLINE DERIVATIVES AS NON-RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-08-19 | — | — | WO | disclosed |