Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.66 |
| ▸ | ABL1 | P00519 | 4/20 | 0.66 |
| ▸ | BCR | P11274 | 3/20 | 0.66 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.60 |
| ▸ | WEE1 | P30291 | 2/20 | 0.60 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 3/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | CASK | O14936 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6684408 | 0.89 | SRC (0.76) | SRCABL1BCRFYNMAP2K1 | |
| SCHEMBL6689932 | 0.87 | SRC (0.61) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL6688317 | 0.87 | SRC (0.61) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL6691994 | 0.81 | SRC (0.64) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL6832341 | 0.79 | SRC (0.72) | SRCABL1BCRFYNMAP2K1 | |
| SCHEMBL677073 | 0.78 | SRC (0.92) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL30453317 | 0.78 | SRC (0.92) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL6832310 | 0.78 | SRC (0.74) | SRCABL1BCRFYNMAP2K1 | |
| SCHEMBL25418454 | 0.78 | WEE2 (0.80) | SRCABL1BCRWEE2WEE1 | |
| SCHEMBL676484 | 0.78 | SRC (0.92) | SRCABL1BCRWEE2WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069250-A1 | 3-CYANO-QUINOLINE DERIVATIVES AS NON-RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-08-19 | — | — | WO | disclosed |