Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831174 | 0.77 | GAA (0.43) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL6692116 | 0.73 | NPSR1 (0.46) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL6628661 | 0.70 | HDAC1 (0.71) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL4831169 | 0.69 | HDAC1 (0.46) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL13842115 | 0.68 | HDAC1 (0.68) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL4830987 | 0.68 | IDO1 (0.37) | LMNAHDAC1THRBGAA | |
| SCHEMBL4836756 | 0.66 | THRB (0.44) | LMNAHDAC1THRBELOVL1GAA | |
| SCHEMBL28706324 | 0.65 | THRB (0.56) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL19242711 | 0.65 | NPSR1 (1.00) | NPSR1LMNAHDAC1THRBCYP2C9 | |
| SCHEMBL4836201 | 0.64 | HDAC1 (0.44) | LMNAHDAC1MAPTELOVL1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425284-A2 | FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022852-A2 | FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-20 | — | — | WO | disclosed |