Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | AGER | Q15109 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959293 | 0.98 | GAA (0.50) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL16617543 | 0.90 | GAA (0.46) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL30121315 | 0.89 | GAA (0.54) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL20774219 | 0.88 | TLR9 (0.39) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL10728925 | 0.88 | DNMT1 (0.40) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL20774220 | 0.88 | TLR9 (0.39) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL29771132 | 0.88 | TDP1 (0.39) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL11002709 | 0.86 | TLR9 (0.40) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL10734402 | 0.85 | ALDH1A1 (0.37) | GAACA1CA2MMP2MMP1 | |
| SCHEMBL10728594 | 0.85 | ALDH1A1 (0.37) | GAACA1CA2MMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921585-B2 | Method of synthesis of substituted hexitols such as dianhydrogalactitol | DEL MAR PHARMACEUTICALS (CA) | 2014-12-30 | — | — | US | claimed |
| EP-2606020-B1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2018-12-26 | — | — | EP | disclosed |
| US-9630938-B2 | Method of synthesis of substituted hexitols such as dianhydrogalactitol | DELMAR PHARMACEUTICALS, INC. (CA) | 2017-04-25 | — | — | US | disclosed |
| US-20150329511-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (BC) LTD. (CA) | 2015-11-19 | — | — | US | disclosed |
| US-9085544-B2 | Method of synthesis of substituted hexitols such as dianhydrogalactitol | DEL MAR PHARMACEUTICALS (CA) | 2015-07-21 | — | — | US | disclosed |
| US-8921585-B2 | Method of synthesis of substituted hexitols such as dianhydrogalactitol | DEL MAR PHARMACEUTICALS (CA) | 2014-12-30 | — | — | US | disclosed |
| US-20140155638-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (BC) LTD. (CA) | 2014-06-05 | — | — | US | disclosed |
| US-20140066642-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2014-03-06 | — | — | US | disclosed |
| US-8563758-B2 | Method of synthesis of substituted hexitols such as dianhydrogalactitol | DEL MAR PHARMACEUTICALS (CA) | 2013-10-22 | — | — | US | disclosed |
| US-20130211111-A1 | METHOD OF SYNTHESIS OF SUBSTISTUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2013-08-15 | — | — | US | disclosed |
| EP-2606020-A2 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | Del Mar Pharmaceuticals (CA) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024368-A2 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155638-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DDOST, DAD1, KRTCAP2 | GAA 827/4885CA1 202/4885CA2 150/4885 |
| US-20140066642-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DDOST, DAD1, KRTCAP2 | GAA 827/4885CA1 202/4885CA2 150/4885 |
| US-20150329511-A1 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DDOST, DAD1, KRTCAP2 | GAA 827/4885CA1 202/4885CA2 150/4885 |
| US-20130211111-A1 | METHOD OF SYNTHESIS OF SUBSTISTUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL | DDOST, DAD1, AGL | GAA 947/4885CA1 170/4885CA2 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.