Sugi Predict

Sugi Predict / Compounds / SCHEMBL6692511

SCHEMBL6692511

SCHEMBL6692511

CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 7/20 0.50
▸ PGR P06401 5/20 0.50
▸ NR3C2 P08235 2/20 0.50
▸ ALDH1A1 P00352 3/20 0.39
▸ MCL1 Q07820 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ HIF1A Q16665 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ MAPT P10636 3/20 0.36
▸ SERPINA6 P08185 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ SLC22A1 O15245 1/20 0.36
▸ SHBG P04278 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ CYP17A1 P05093 2/20 0.35
▸ CYP3A4 P08684 3/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ CHRM1 P11229 1/20 0.34
▸ TBXA2R P21731 1/20 0.34
▸ ADRA1A P35348 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24711588 1.00 AR (0.50) ARPGRNR3C2ALDH1A1MCL1
SCHEMBL6841025 0.86 AR (0.50) ARPGRNR3C2ALDH1A1MCL1
SCHEMBL6841026 0.86 AR (0.50) ARPGRNR3C2ALDH1A1MCL1
SCHEMBL13400873 0.83 AR (0.38) ARPGRNR3C2
SCHEMBL6843518 0.83 AR (0.38) ARPGRNR3C2
SCHEMBL11747587 0.82 AR (0.48) ARPGRNR3C2ALDH1A1MCL1
SCHEMBL14200096 0.81 CYP17A1 (0.54) ARPGRNR3C2ALDH1A1MAPT
SCHEMBL12101456 0.81 CYP17A1 (0.54) ARPGRNR3C2ALDH1A1MAPT
SCHEMBL13397495 0.81 CYP17A1 (0.54) ARPGRNR3C2ALDH1A1MAPT
SCHEMBL8843324 0.81 CYP17A1 (0.54) ARPGRNR3C2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0262201-B1 PROCESS FOR PRODUCING 7$g(a)-PROPYLSTEROIDS SCHERING AKTIENGESELLSCHAFT (DE) 1991-02-27 — — EP claimed
US-20040209853-A1 Orally active 7.alpha.-alkyl androgens AKZO NOBEL N.V. (NL) 2004-10-21 — — US disclosed
US-6756366-B1 19-NORTESTOSTERONE DERIVATIVES; ORALLY ACTIVE; HIGH POTENCY AKZO NOBEL N.V. (NL) 2004-06-29 — — US disclosed
US-20040010138-A1 Process for the production of 7alpha-methyl steroids SCHERING AG (DE) 2004-01-15 — — US disclosed
EP-1212345-B1 ORALLY ACTIVE 7-ALPHA-ALKYL ANDROGENS AKZO NOBEL NV (NL) 2003-08-06 — — EP disclosed
EP-1212345-A2 ORALLY ACTIVE 7.ALPHA.-ALKYL ANDROGENS Akzo Nobel N.V. (NL) 2002-06-12 — — EP disclosed
WO-2000059920-A2 ORALLY ACTIVE 7.ALPHA.-ALKYL ANDROGENS AKZO NOBEL N.V. (NL) 2000-10-12 — — WO disclosed
EP-0262201-B1 PROCESS FOR PRODUCING 7$g(a)-PROPYLSTEROIDS SCHERING AKTIENGESELLSCHAFT (DE) 1991-02-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040010138-A1 Process for the production of 7alpha-methyl steroids CYP21A2, CYP17A1, CYP4A11 AR 290/4885PGR 701/4885NR3C2 26/4885
US-20040209853-A1 Orally active 7.alpha.-alkyl androgens NR5A1, AR, SHBG AR 2/4885PGR 151/4885NR3C2 28/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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