Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | NAT1 | P18440 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | ARAF | P10398 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692556 | 1.00 | EGFR (0.43) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6686685 | 0.81 | RAF1 (0.54) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6690291 | 0.77 | RAF1 (0.47) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6690293 | 0.77 | RAF1 (0.47) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL1394813 | 0.76 | RAF1 (0.71) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL5083132 | 0.76 | RAF1 (0.71) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6692724 | 0.75 | RAF1 (0.46) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6692727 | 0.75 | RAF1 (0.46) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL6696048 | 0.74 | ERBB2 (0.46) | EGFRERBB2DHFRRAF1PLK4 | |
| SCHEMBL6696046 | 0.74 | ERBB2 (0.46) | EGFRERBB2DHFRRAF1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069998-A2 | OXINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2004-08-19 | — | — | WO | disclosed |