Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | CFTR | P13569 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6684573 | 0.94 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6843889 | 0.90 | PDE4D (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6686338 | 0.90 | PDE4D (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6688282 | 0.90 | PDE4D (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6687107 | 0.89 | PDE4D (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6657358 | 0.89 | SMN1; SMN2 (0.49) | PDE4APDE4BPDE4CPDE4DCFTR | |
| SCHEMBL6659102 | 0.89 | PDE4D (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6686947 | 0.88 | INSR (0.37) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6686722 | 0.88 | PDE4D (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6683785 | 0.88 | PDE4D (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435958-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032993-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |