Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 2/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19421536 | 0.75 | MEN1 (0.40) | VEGFAEGLN1ALDH1A1KDM4EMAPT | |
| SCHEMBL15799041 | 0.75 | BRD4 (0.50) | VEGFAEGLN1BRD4BRD2BRD3 | |
| SCHEMBL3181686 | 0.73 | BRD4 (0.56) | BRD4BRD2BRD3BRDTALDH1A1 | |
| SCHEMBL15803919 | 0.73 | HDAC10 (0.51) | BRD4BRD2BRD3BRDTALDH1A1 | |
| SCHEMBL12376651 | 0.72 | BRD4 (0.73) | BRD4BRD2BRD3BRDTALDH1A1 | |
| SCHEMBL16509736 | 0.72 | BRD4 (0.56) | VEGFAEGLN1BRD4BRD2BRD3 | |
| SCHEMBL271606 | 0.71 | EGLN1 (1.00) | VEGFAEGLN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL272200 | 0.71 | EGLN1 (1.00) | VEGFAEGLN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL27766860 | 0.70 | ALDH1A1 (0.53) | BRD4BRD2BRD3BRDTALDH1A1 | |
| SCHEMBL3272017 | 0.70 | BCHE (0.55) | ALDH1A1KDM4ELMNAPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |