Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694051 | 0.91 | HDAC1 (0.44) | HDAC1HDAC6CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6689259 | 0.88 | HDAC1 (0.40) | HDAC1HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL5207833 | 0.88 | HDAC1 (0.51) | HDAC1HDAC6KDM4EKMT2ACSNK2A2 | |
| SCHEMBL6693631 | 0.85 | HDAC1 (0.45) | HDAC1HDAC6KDM4EMAPTPLA2G2A | |
| SCHEMBL6774729 | 0.84 | HDAC1 (0.45) | HDAC1HDAC6NPSR1KDM4EALDH1A1 | |
| SCHEMBL6689321 | 0.84 | HDAC1 (0.42) | HDAC1HDAC6NPSR1KDM4EALDH1A1 | |
| SCHEMBL6693115 | 0.83 | FABP3 (0.45) | HDAC1HDAC6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6691809 | 0.83 | HDAC1 (0.44) | HDAC1HDAC6NPSR1KDM4EMAPT | |
| SCHEMBL6691242 | 0.82 | HDAC1 (0.46) | HDAC1HDAC6KDM4EMAPTPLA2G2A | |
| SCHEMBL6692697 | 0.82 | HDAC1 (0.41) | HDAC1HDAC6KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |