Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | TSPO | P30536 | 2/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29863082 | 0.91 | HTR6 (0.51) | HTR6TSPOPLA2G2AFABP4PLA2G10 | |
| SCHEMBL818490 | 0.91 | HTR6 (0.51) | HTR6TSPOPLA2G2AFABP4PLA2G10 | |
| SCHEMBL27862241 | 0.91 | HTR6 (0.47) | HTR6TSPOPLA2G2APLA2G10 | |
| SCHEMBL818425 | 0.91 | HTR6 (0.47) | HTR6PLA2G2AFABP4PLA2G10 | |
| SCHEMBL29862534 | 0.91 | HTR6 (0.47) | HTR6PLA2G2AFABP4PLA2G10 | |
| SCHEMBL6129641 | 0.90 | HTR6 (0.47) | HTR6PLA2G2AFABP4PLA2G10 | |
| SCHEMBL6129643 | 0.90 | HTR6 (0.47) | HTR6PLA2G2AFABP4PLA2G10 | |
| SCHEMBL6699097 | 0.88 | HTR6 (0.45) | HTR6TSPOPLA2G2APLA2G10 | |
| SCHEMBL819144 | 0.88 | HTR6 (0.45) | HTR6TSPOPLA2G2AFABP4PLA2G10 | |
| SCHEMBL29862390 | 0.88 | HTR6 (0.42) | HTR6TSPOPLA2G2AFABP4PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |