SCHEMBL6693695

SCHEMBL6693695

COc1cccc2sc(SSc3nc4c(OC)cccc4s3)nc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.63
TDP1 Q9NUW8 4/20 0.63
CYP3A4 P08684 1/20 0.63
MAPT P10636 4/20 0.58
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
KDM4E B2RXH2 4/20 0.58
GAA P10253 2/20 0.58
HPGD P15428 5/20 0.52
RAB9A P51151 4/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
NPC1 O15118 3/20 0.52
TP53 P04637 2/20 0.52
NFKB1 P19838 1/20 0.52
NFKB2 Q00653 1/20 0.52
RELA Q04206 1/20 0.52
DYRK1A Q13627 1/20 0.52
PPARG P37231 2/20 0.49
TSHR P16473 1/20 0.49
NCOA2 Q15596 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6899691 0.90 ALDH1A1 (0.63) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL2336046 0.88 ALDH1A1 (0.61) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL8635308 0.87 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL31294145 0.83 ALDH1A1 (0.55) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL6689165 0.82 ALDH1A1 (0.66) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL6689383 0.81 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL6691887 0.81 ALDH1A1 (0.52) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL6689028 0.80 ALDH1A1 (0.51) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL3072555 0.79 ALDH1A1 (0.67) ALDH1A1TDP1CYP3A4MAPTMEN1
SCHEMBL3123406 0.79 ALDH1A1 (0.67) ALDH1A1TDP1CYP3A4MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-0854168-B1 Rubber composition BRIDGESTONE CORP (JP) 2003-04-02 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed