Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444901 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP2C19OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6693741 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP2C19OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7656846 | 0.83 | NR1I2 (0.34) | CYP2D6CYP2C19NR1I2ALBPDE4D | |
| SCHEMBL7656839 | 0.78 | NR1I2 (0.36) | NR1I2ALBPDE4D | |
| SCHEMBL9471063 | 0.76 | CYP2D6 (0.51) | CYP2D6CYP2C19OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9667532 | 0.76 | CYP2D6 (0.38) | CYP2D6CYP2C19OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6691481 | 0.76 | NR1I2 (0.41) | NR1I2ALBPDE4D | |
| SCHEMBL6691478 | 0.76 | NR1I2 (0.41) | NR1I2ALBPDE4D | |
| SCHEMBL332026 | 0.76 | NR1I2 (0.41) | NR1I2ALBPDE4D | |
| SCHEMBL13790123 | 0.76 | NR1I2 (0.41) | NR1I2ALBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878548-B1 | Multistep process for the preparation of (1S,4R)- and/or (1R,4S)-4-(2-Amino-6-Chlor-9-H-purin-9-yl)-2-cyclopentene-1-methanol | LONZA AG (CH) | 2004-09-01 | — | — | EP | disclosed |
| EP-0434450-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1999-07-07 | — | — | EP | disclosed |
| EP-0921114-A1 | Intermediates to therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1999-06-09 | — | — | EP | disclosed |
| EP-0921121-A1 | Intermediates to therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1999-06-09 | — | — | EP | disclosed |
| EP-0349242-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1995-03-22 | — | — | EP | disclosed |
| EP-0366385-B1 | GUANINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-06-09 | — | — | EP | disclosed |
| US-5206435-A | Viricides; HIV, aides | BURROUGHS WELLCOME CO. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0479822-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5089500-A | Viricides; hepatitis, aids | BURROUGHS WELLCOME CO. (US) | 1992-02-18 | — | — | US | disclosed |
| US-5087697-A | Aids, viricides | BURROUGHS WELLCOME CO. (US) | 1992-02-11 | — | — | US | disclosed |
| US-5049671-A | Hepatitis, AIDS | BURROUGHS WELLCOME CO. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5034394-A | Therapeutic nucleosides | BURROUGHS WELLCOME CO. (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0434450-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |
| WO-1991000282-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-10 | — | — | WO | disclosed |
| EP-0366385-A1 | Guanine derivatives having antiviral activity and their pharmaceutically acceptable salts | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |
| EP-0361831-A1 | Antiviral nucleoside combination | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-04-04 | — | — | EP | disclosed |
| EP-0349242-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-01-03 | — | — | EP | disclosed |