Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035241 | 0.91 | MAP2K1 (0.53) | MAP2K1MAP2K2IDO1KDM4EALDH1A1 | |
| SCHEMBL6035385 | 0.85 | MAP2K1 (0.53) | MAP2K1MAP2K2IDO1GPR52MT-CO2 | |
| SCHEMBL6035378 | 0.85 | MAP2K1 (0.48) | MAP2K1MAP2K2IDO1KDM4EALDH1A1 | |
| SCHEMBL5676551 | 0.85 | HPGD (0.55) | MAP2K1MAP2K2IDO1GPR52 | |
| SCHEMBL6035461 | 0.84 | MAP2K1 (0.55) | MAP2K1MAP2K2IDO1GPR52JAK1 | |
| SCHEMBL6036120 | 0.84 | KMT2A (0.49) | MAP2K1MAP2K2KDM4EALDH1A1MAPT | |
| SCHEMBL27583296 | 0.82 | MAP2K1 (0.61) | MAP2K1MAP2K2PTGS2GPR52JAK1 | |
| SCHEMBL15603461 | 0.82 | MAP2K1 (0.70) | MAP2K1MAP2K2 | |
| SCHEMBL7715685 | 0.82 | IDO1 (0.48) | MAP2K1MAP2K2IDO1PTGS2KDM4E | |
| SCHEMBL6036200 | 0.82 | KMT2A (0.48) | MAP2K1MAP2K2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696440-B1 | ADMINISTERING MITOGEN ACTIVATED PROTEIN KINASE(MEK) INHIBITORS COMPRISING SECONDARY CARBOCYCLIC AMINES, AS ANTIASTHMATIC AGENTS | WARNER-LAMBERT COMPANY | 2004-02-24 | — | — | US | disclosed |