Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 3/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11603149 | 0.99 | MAOA (0.51) | MAOAMAOBTAAR1DPP4CCR1 | |
| Hydrochloric Acid SCHEMBL11602646 | 0.99 | MAOA (0.51) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11656657 | 0.92 | MAOA (0.45) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11602768 | 0.92 | MAOA (0.45) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11602929 | 0.92 | MAOA (0.45) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11601863 | 0.92 | CCR1 (0.53) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11603862 | 0.92 | CCR1 (0.53) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11601401 | 0.92 | MEN1 (0.49) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11601959 | 0.92 | MEN1 (0.49) | MAOAMAOBTAAR1DPP4CCR1 | |
| SCHEMBL11602881 | 0.91 | CCR1 (0.51) | MAOAMAOBTAAR1DPP4CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3553083-B2 | — | — | 2004-08-11 | — | — | JP | claimed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | claimed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | claimed |
| US-4069223-A | ANTIDIARRHEA | G. D. SEARLE & CO. (US) | 1978-01-17 | — | — | US | claimed |
| US-6576650-B1 | No central nervous system side effects | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-10 | — | — | US | disclosed |
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-6166039-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIV. OF CALIFORNIA (US) | 2000-12-26 | — | — | US | disclosed |
| US-5994372-A | ANTIDIARRHEA COMPOUND | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-30 | — | — | US | disclosed |
| US-5849761-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-15 | — | — | US | disclosed |
| US-4069223-A | ANTIDIARRHEA | G. D. SEARLE & CO. (US) | 1978-01-17 | — | — | US | disclosed |