Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695074 | 0.89 | MDM2 (0.42) | MDM2NR3C2LPAR1MDM4SCN9A | |
| SCHEMBL15853710 | 0.79 | NR3C2 (0.40) | MDM2NR3C2MDM4SCN9ANR3C1 | |
| SCHEMBL9061421 | 0.76 | MDM2 (0.40) | MDM2NR3C2MDM4NR3C1DPP4 | |
| SCHEMBL564412 | 0.76 | MDM2 (0.44) | MDM2NR3C2MDM4DPP4DPP7 | |
| SCHEMBL30202666 | 0.75 | GPR139 (0.48) | MDM2NR3C2 | |
| SCHEMBL30938844 | 0.75 | NR3C2 (0.53) | MDM2NR3C2MDM4NR3C1 | |
| SCHEMBL30938843 | 0.75 | NR3C2 (0.53) | MDM2NR3C2MDM4NR3C1 | |
| SCHEMBL22289631 | 0.75 | MDM2 (0.43) | MDM2NR3C2MDM4DPP4DPP7 | |
| SCHEMBL23212834 | 0.74 | PDE2A (0.59) | MDM2NR3C2MDM4DPP4DPP7 | |
| SCHEMBL17215540 | 0.74 | PDE2A (0.59) | MDM2NR3C2MDM4DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5286912-A | — | — | None | — | — | JP | disclosed |
| JP-5286906-A | — | — | None | — | — | JP | disclosed |
| JP-5286909-A | — | — | None | — | — | JP | disclosed |
| US-9580444-B2 | Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof | SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2975040-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | Sagami Chemical Research Institute (JP) | 2016-01-20 | — | — | EP | disclosed |
| EP-0950657-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | LILLY CO ELI (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0950657-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0650957-A1 | ANILINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1995-05-03 | — | — | EP | disclosed |
| JP-H05286906-A | CARBONIC ACID ESTER DERIVATIVE AND ITS PRODUCTION | SUMITOMO CHEM CO LTD | 1993-11-02 | — | — | JP | disclosed |
| JP-H05286912-A | PRODUCTION OF AMINOPHENOL DERIVATIVE | SUMITOMO CHEM CO LTD | 1993-11-02 | — | — | JP | disclosed |
| JP-H05286909-A | NITRIBENZENE DERIVATIVE AND ITS PRODUCTION | SUMITOMO CHEM CO LTD | 1993-11-02 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | DDT, PDHX, CYP4X1 | MDM2 994/4885NR3C2 1107/4885LPAR1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.