Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.80 |
| ▸ | CTSL | P07711 | 6/20 | 0.80 |
| ▸ | CTSB | P07858 | 4/20 | 0.80 |
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934819 | 1.00 | CTSK (0.80) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL6987536 | 0.92 | CTSK (0.75) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6981246 | 0.92 | CTSK (0.75) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6683037 | 0.92 | CTSK (0.76) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL5934960 | 0.92 | CTSK (0.76) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL5935121 | 0.91 | CTSK (0.75) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL6681030 | 0.83 | CTSK (0.64) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL6686640 | 0.83 | CTSK (0.64) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL5934894 | 0.83 | CTSK (0.64) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7165396 | 0.83 | CTSK (0.78) | CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058238-A1 | USE OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | claimed |
| EP-0934291-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| EP-0934291-A4 | — | SMITHKLINE BEECHAM CORP (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1997016433-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |