Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539755 | 0.87 | CRBN (0.53) | CRBNDDB1ALDH1A1HTT | |
| SCHEMBL4395823 | 0.83 | CRBN (0.58) | CRBNPOLBDDB1KMT2AHTT | |
| SCHEMBL6700609 | 0.76 | CRBN (0.55) | CRBNDDB1MEN1KMT2AALDH1A1 | |
| SCHEMBL4390852 | 0.74 | CRBN (0.55) | CRBNPOLBDDB1MEN1KMT2A | |
| SCHEMBL4390838 | 0.72 | GAA (0.47) | CRBNDDB1CA1CA2 | |
| SCHEMBL31443938 | 0.72 | CRBN (0.48) | CRBNDDB1 | |
| SCHEMBL23551748 | 0.71 | HDAC8 (0.41) | CRBNDDB1ALDH1A1HPGDNPC1 | |
| SCHEMBL31730142 | 0.71 | CRBN (0.52) | CRBNPOLBDDB1KMT2ASMN1; SMN2 | |
| SCHEMBL23541160 | 0.71 | CRBN (0.46) | CRBNDDB1 | |
| SCHEMBL4400645 | 0.71 | CRBN (0.58) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1185215-C | Substituted glutarimides and use thereof IL-12 production inhibitors | GRUENENTHAL GMBH (DE) | 2005-01-19 | — | — | CN | disclosed |
| US-20040048859-A1 | Substituted glutarimides and their use as inhibitors of IL-12 production | GRUENENTHAL GMBH (DE) | 2004-03-11 | — | — | US | disclosed |
| US-20030064987-A1 | Substituted glutarimides and their use as inhibitors of IL-12 production | GRUENENTHAL GMBH | 2003-04-03 | — | — | US | disclosed |
| CN-1394201-A | Substituted glutarimides and use thereof IL-12 production inhibitors | GRUENENTHAL GMBH (DE) | 2003-01-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048859-A1 | Substituted glutarimides and their use as inhibitors of IL-12 production | GCDH, IL4I1, IL2 | CRBN 949/4885POLB 3113/4885DDB1 2435/4885 |
| US-20030064987-A1 | Substituted glutarimides and their use as inhibitors of IL-12 production | GCDH, IL4I1, IL2 | CRBN 949/4885POLB 3113/4885DDB1 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.