Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 15/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.58 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250645 | 0.88 | CDK2 (0.72) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL5725714 | 0.88 | CCNT1 (0.62) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6194323 | 0.88 | CDK2 (0.54) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6191533 | 0.86 | CCNA2 (0.63) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL5725752 | 0.86 | CDK2 (0.76) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6694011 | 0.85 | CCNT1 (0.64) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6195386 | 0.85 | CCNT1 (0.55) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6211465 | 0.84 | CCNA2 (0.56) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6193477 | 0.84 | CCNA2 (0.52) | CDK2CCNA2CCNT1CDK4CCND1 | |
| SCHEMBL6193150 | 0.83 | CCNT1 (0.58) | CDK2CCNA2CCNT1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | PFIZER, INC. | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | MKI67, TK1, CDK2 | CDK2 3/4885CCNA2 138/4885CCNT1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.