Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL133050 | 0.95 | SLC34A1 (0.64) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL29675038 | 0.95 | — | — | |
| Phosphoric Acid SCHEMBL11660 | 0.95 | — | — | |
| Phosphoric Acid SCHEMBL736578 | 0.95 | SLC34A1 (0.64) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL25422657 | 0.90 | SLC34A1 (0.58) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL9306687 | 0.90 | SLC34A1 (0.58) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL15353579 | 0.90 | SLC34A1 (0.58) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL20540375 | 0.90 | SLC34A1 (0.73) | SLC34A1KDM4ECYP2C19KMT2ALMNA | |
| Phosphoric Acid SCHEMBL20942976 | 0.90 | — | — | |
| Phosphoric Acid SCHEMBL3390891 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964588-B1 | COATING SYSTEM BASED ON A COMBINATION OF MONOALUMINUM PHOSPHATE WITH MAGNESIUM OXIDE | BUDENHEIM KG CHEMISCHE FABRIK (DE) | 2019-10-02 | — | — | EP | disclosed |
| US-10426740-B1 | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues | AVM BIOTECHNOLOGY, LLC (US) | 2019-10-01 | — | — | US | disclosed |
| EP-3530274-A1 | DEXAMETHASONE TO REDUCE STEM CELL ACCUMULATION IN THE SPLEEN | Deisher, Theresa (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-2605765-B1 | DEXAMETHASONE FOR USE IN TREATING OSTEOARTHRITIS, LIVER FAILURE, TYPE-2 DIABETES MELLITUS, STROKE AND PARKINSON'S DISEASE, IN COMBINATION WITH STEM CELL TREATMENT | DEISHER THERESA (US) | 2019-05-08 | — | — | EP | disclosed |
| US-9975809-B2 | Coating system based on a combination of monoaluminum phosphate with magnesium oxide | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2018-05-22 | — | — | US | disclosed |
| US-9962408-B2 | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues | AVM BIOTECHNOLOGY LLC (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170128493-A1 | COMPOSITIONS AND METHODS TO INHIBIT STEM CELL AND PROGENITOR CELL BINDING TO LYMPHOID TISSUE AND FOR REGENERATING GERMINAL CENTERS IN LYMPHATIC TISSUES | AVM BIOTECHNOLOGY, LLC | 2017-05-11 | — | — | US | disclosed |
| US-20160009600-A1 | COATING SYSTEM BASED ON A COMBINATION OF MONOALUMINUM PHOSPHATE WITH MAGNESIUM OXIDE | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2016-01-14 | — | — | US | disclosed |
| EP-2964588-A1 | COATING SYSTEM BASED ON A COMBINATION OF MONOALUMINUM PHOSPHATE WITH MAGNESIUM OXIDE | Chemische Fabrik Budenheim KG (DE) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135407-A1 | COATING SYSTEM BASED ON A COMBINATION OF MONOALUMINUM PHOSPHATE WITH MAGNESIUM OXIDE | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2014-09-12 | — | — | WO | disclosed |
| EP-2605765-A2 | COMPOSITIONS AND METHODS TO INHIBIT STEM CELL AND PROGENITOR CELL BINDING TO LYMPHOID TISSUE AND FOR REGENERATING GERMINAL CENTERS IN LYMPHATIC TISSUES | Deisher, Theresa (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024519-A2 | COMPOSITIONS AND METHODS TO INHIBIT STEM CELL AND PROGENITOR CELL BINDING TO LYMPHOID TISSUE AND FOR REGENERATING GERMINAL CENTERS IN LYMPHATIC TISSUES | DEISHER THERESA (US) | 2012-02-23 | — | — | WO | disclosed |
| US-20120045435-A1 | COMPOSITIONS AND METHODS TO INHIBIT STEM CELL AND PROGENITOR CELL BINDING TO LYMPHOID TISSUE AND FOR REGENERATING GERMINAL CENTERS IN LYMPHATIC TISSUES | AVM BIOTECHNOLOGY, LLC | 2012-02-23 | — | — | US | disclosed |
| EP-0313433-A1 | Process for the preparation of crystalline acid sodium and aluminium phosphates | RHONE-POULENC CHIMIE (FR) | 1989-04-26 | — | — | EP | disclosed |