Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668537 | 0.91 | ALDH1A1 (0.43) | MAPK14CHRM5LMNAALDH1A1MAPK1 | |
| SCHEMBL6644394 | 0.82 | MAPK14 (0.48) | MAPK14CHRM5LMNAALDH1A1MAPK1 | |
| SCHEMBL6669384 | 0.78 | MAPK14 (0.43) | MAPK14CHRM5LMNAALDH1A1MAPK1 | |
| SCHEMBL6667226 | 0.77 | MAPK14 (0.51) | MAPK14CHRM5TSHR | |
| SCHEMBL6667945 | 0.77 | MAPK14 (0.53) | MAPK14CHRM5TSHR | |
| SCHEMBL6666877 | 0.76 | MAPK14 (0.42) | MAPK14CHRM5LMNAALDH1A1MAPK1 | |
| SCHEMBL6670125 | 0.76 | MAPK14 (0.42) | MAPK14CHRM5LMNAALDH1A1MAPK1 | |
| SCHEMBL6672647 | 0.75 | MAPK14 (0.48) | MAPK14CHRM5 | |
| SCHEMBL6668236 | 0.74 | MAPK14 (0.50) | MAPK14CHRM5 | |
| SCHEMBL6668734 | 0.74 | MAPK14 (0.48) | MAPK14CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345603-A4 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1345603-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002058695-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2002-08-01 | — | — | WO | disclosed |