Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 4/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 4/20 | 1.00 |
| ▸ | GRIA1 | P42261 | 4/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 4/20 | 1.00 |
| ▸ | GRIA3 | P42263 | 4/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 4/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 4/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 4/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 4/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 4/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 1.00 |
| ▸ | GRIK1 | P39086 | 2/20 | 1.00 |
| ▸ | GRIK2 | Q13002 | 2/20 | 1.00 |
| ▸ | GRIK3 | Q13003 | 2/20 | 1.00 |
| ▸ | GRIK4 | Q16099 | 2/20 | 1.00 |
| ▸ | GRIK5 | Q16478 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349897 | 0.88 | GRIN2D (0.78) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL11349852 | 0.88 | GRIN2D (0.78) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9703926 | 0.85 | GRIN2D (0.74) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9705832 | 0.85 | GRIN2D (0.74) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL6603624 | 0.83 | GRIN2D (0.70) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL6608200 | 0.83 | GRIN2D (0.70) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9703949 | 0.83 | GRIN2D (0.70) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9704899 | 0.81 | GRIN2D (0.71) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL11256884 | 0.81 | GRIN2D (0.68) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9704358 | 0.81 | GRIN2D (0.68) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| EP-0029658-A1 | Salts of dihalo-2-quinoxaline carboxylic acids, their preparation and pharmaceutical formulations containing them | ELI LILLY AND COMPANY (US) | 1981-06-03 | — | — | EP | claimed |
| US-4252954-A | VIRICIDES | ELI LILLY AND COMPANY (US) | 1981-02-24 | — | — | US | claimed |
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | UNIV NORTHWESTERN (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | UNIV NORTHWESTERN (US) | 2017-03-16 | — | — | US | disclosed |
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| US-4355030-A | Antiviral combinations | ELI LILLY AND COMPANY (US) | 1982-10-19 | — | — | US | disclosed |
| US-4289773-A | ETHYL 6,7-DIBROMO-3,4-DIHYDRO-3-OXOQUINOXALINE CARBOXYLATE AND A HINDERED AMINE | ELI LILLY AND COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| EP-0029658-A1 | Salts of dihalo-2-quinoxaline carboxylic acids, their preparation and pharmaceutical formulations containing them | ELI LILLY AND COMPANY (US) | 1981-06-03 | — | — | EP | disclosed |
| US-4271162-A | ETHYL 6,7-DICHLORO-3,4-DIHYDRO-3-ONOQUINOXALINE CARBOXYLATE AND 1-AMINOADAMANTANE | ELI LILLY AND COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| US-4264600-A | VIRICIDES | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4252954-A | VIRICIDES | ELI LILLY AND COMPANY (US) | 1981-02-24 | — | — | US | disclosed |
| EP-0020836-A1 | Antiviral combinations | ELI LILLY AND COMPANY (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4210647-A | INFLUENZA VIRUS, ETHYL 6,7-DIBROMO-3,4-DIHYDRO-3-OXO-2-QUINOXALINECARBOXYLATE, 1-AMINOADAMANTANE | ELI LILLY AND COMPANY (US) | 1980-07-01 | — | — | US | disclosed |
| EP-0010426-A1 | Pharmaceutical composition containing 3,4-dihydro-3-oxo-2-quinoxalines, novel such quinoxalines and processes for the production thereof | ELI LILLY AND COMPANY (US) | 1980-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | GRIN1, GRIN2A, GRIN3A | GRIN2D 15/4885GRIN3B 5/4885GRIA1 11/4885 |
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | NQO2, NQO1, CYP2C8 | GRIN2D 1540/4885GRIN3B 1596/4885GRIA1 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.