Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161776 | 0.87 | LMNA (0.56) | NQO2FTOMAPTMEN1KMT2A | |
| SCHEMBL22070131 | 0.83 | LCK (0.41) | MAPTMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL163865 | 0.83 | CA12 (0.57) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL23377968 | 0.81 | ESR1 (0.44) | FTOMAPTMEN1KMT2AHPGD | |
| SCHEMBL163060 | 0.80 | LMNA (0.57) | NQO2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL25837458 | 0.80 | BCL2L1 (0.54) | MAPTMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL162582 | 0.79 | NQO2 (0.44) | NQO2FTOTRPM4MAPTMEN1 | |
| SCHEMBL161258 | 0.79 | CA12 (0.57) | NQO2TRPM4MAPTMEN1KMT2A | |
| SCHEMBL162778 | 0.78 | ESR1 (0.64) | LMNATDP1L3MBTL1SERPINE1 | |
| SCHEMBL7308187 | 0.78 | MAPT (0.62) | NQO2TRPM4MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |