Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408291 | 0.98 | — | — | |
| SCHEMBL709331 | 0.98 | PSMD14 (0.53) | PSMD14MAPK1NUDT1AXLKDM4E | |
| SCHEMBL12565 | 0.98 | — | — | |
| SCHEMBL2590859 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| Bromide SCHEMBL1435739 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| Hydrochloric Acid SCHEMBL5283362 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| SCHEMBL30051791 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| Ammonia Solution, Strong SCHEMBL5790263 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| Hydrochloric Acid SCHEMBL27527111 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E | |
| SCHEMBL3087140 | 0.95 | PSMD14 (0.52) | PSMD14MAPK1NUDT1AXLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | KCNJ2, KCNN1, KCNN2 | PSMD14 3343/4885MAPK1 518/4885NUDT1 3595/4885 |
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | KCNJ2, KCNN1, KCNN2 | PSMD14 3343/4885MAPK1 518/4885NUDT1 3595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.