SCHEMBL670046

SCHEMBL670046

COc1cccc(C(O)(CCN(C)C)C(C)C)c1

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.42
CALM1 P0DP23 1/20 0.40
CAMKK2 Q96RR4 1/20 0.40
AOC3 Q16853 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL669922 1.00 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
SCHEMBL670608 1.00 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
Hydrochloric Acid SCHEMBL670045 0.99 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
Hydrochloric Acid SCHEMBL16742846 0.99 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
SCHEMBL15109995 0.82 BCL2 (0.55) SMN1; SMN2
SCHEMBL2558812 0.81 SMN1; SMN2 (0.45) ALDH1A1SMN1; SMN2
SCHEMBL2554080 0.81 SMN1; SMN2 (0.45) ALDH1A1SMN1; SMN2
SCHEMBL354856 0.79 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
SCHEMBL117975 0.79 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3
SCHEMBL18897543 0.79 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2CALM1CAMKK2AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3063125-A1 NOVEL INTERMEDIATE OF TAPENTADOL Sun Pharma Advanced Research Company (IN) 2016-09-07 EP claimed
WO-2015075744-A1 NOVEL INTERMEDIATE OF TAPENTADOL SUN PHARMA ADVANCED RESEARCH COMPANY (IN) 2015-05-28 WO claimed
WO-2013105109-A1 PROCESS FOR THE PREPARATION OF TAPENTADOL INDOCO REMEDIES LIMITED (IN) 2013-07-18 WO claimed
EP-2545028-A1 A NOVEL STEREOSPECIFIC SYNTHESIS OF (-) (2S,3S)-1-DIMETHYLAMINO-3-(3-METHOXYPHENYL)-2-METHYL PENTAN-3-OL Symed Labs Limited (IN) 2013-01-16 EP claimed
EP-2542521-A2 IMPROVED RESOLUTION METHODS FOR ISOLATING DESIRED ENANTIOMERS OF TAPENTADOL INTERMEDIATES AND USE THEREOF FOR THE PREPARATION OF TAPENTADOL Actavis Group Ptc Ehf (IS) 2013-01-09 EP claimed
WO-2012101649-A1 A NOVEL STEREOSPECIFIC SYNTHESIS OF (-) (2S,3S)-1-DIMETHYLAMINO-3-(3-METHOXYPHENYL)-2-METHYL PENTAN-3-OL SYMED LABS LIMITED (IN) 2012-08-02 WO claimed
WO-2011107876-A2 IMPROVED RESOLUTION METHODS FOR ISOLATING DESIRED ENANTIOMERS OF TAPENTADOL INTERMEDIATES AND USE THEREOF FOR THE PREPARATION OF TAPENTADOL ACTAVIS GROUP PTC EHF (IS) 2011-09-09 WO claimed
US-7410965-B2 Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol GRUENENTHAL GMBH (DE) 2008-08-12 US claimed
EP-3063125-A1 NOVEL INTERMEDIATE OF TAPENTADOL Sun Pharma Advanced Research Company (IN) 2016-09-07 EP disclosed
WO-2015075744-A1 NOVEL INTERMEDIATE OF TAPENTADOL SUN PHARMA ADVANCED RESEARCH COMPANY (IN) 2015-05-28 WO disclosed
WO-2015075678-A1 A NOVEL PROCESS FOR THE PREPARATION OF 1-PHENYL-3-AMINOPROPANE DERIVATIVES UNIMARK REMEDIES LTD. (IN) 2015-05-28 WO disclosed
WO-2013111161-A2 PROCESS FOR THE PREPARATION OF 3-ARYL-2-METHYL-PROPANAMINE DERIVATIVES AND POLYMORPHS THEREOF MSN LABORATORIES LIMITED (IN) 2013-08-01 WO disclosed
EP-2619174-A1 PROCESS FOR PREPARING L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVE Ind-Swift Laboratories Limited (IN) 2013-07-31 EP disclosed
WO-2013105109-A1 PROCESS FOR THE PREPARATION OF TAPENTADOL INDOCO REMEDIES LIMITED (IN) 2013-07-18 WO disclosed
EP-1507519-A1 MEDICAMENT WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE, CONTAINING 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL Grünenthal GmbH (DE) 2005-02-23 EP disclosed
EP-1507521-A1 METABOLITE OF 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTANE-3-OL AND THE USE THEREOF IN THE TREATMENT OF URINARY INCONTINENCE Grünenthal GmbH (DE) 2005-02-23 EP disclosed
EP-1429754-A1 COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE Grünenthal GmbH (DE) 2004-06-23 EP disclosed
WO-2003101440-A1 METABOLITE OF 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTANE-3-OL AND THE USE THEREOF IN THE TREATMENT OF URINARY INCONTINENCE Grünenthal GmbH (DE) 2003-12-11 WO disclosed
WO-2003099267-A1 MEDICAMENT WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE, CONTAINING 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL Grünenthal GmbH (DE) 2003-12-04 WO disclosed
WO-2003024444-A1 COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE Grünenthal GmbH (DE) 2003-03-27 WO disclosed