Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 17/20 | 0.40 |
| ▸ | JAK2 | O60674 | 9/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 7/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670217 | 0.89 | PTK2 (0.46) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL670057 | 0.83 | PTK2 (0.54) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL669191 | 0.79 | PTK2 (0.43) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL670544 | 0.77 | PTK2 (0.63) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL670504 | 0.74 | PTK2 (0.57) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL670216 | 0.72 | PTK2 (0.65) | PTK2JAK2JAK3PTK2BAURKA | |
| SCHEMBL670106 | 0.72 | PTK2 (0.51) | PTK2JAK2JAK3PTK2B | |
| SCHEMBL670678 | 0.71 | PTK2 (0.51) | PTK2JAK2JAK3PTK2B | |
| SCHEMBL10125284 | 0.71 | PTK2 (0.49) | PTK2JAK2JAK3PTK2B | |
| SCHEMBL10125453 | 0.70 | SYK (0.44) | PTK2JAK2JAK3PTK2BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | claimed |
| EP-2606034-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | Merck Patent GmbH (DE) | 2013-06-26 | — | — | EP | claimed |
| WO-2012022408-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | WO | claimed |
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |