Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 20/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670058 | 0.89 | PTK2 (0.40) | PTK2PTK2BJAK2JAK3AURKA | |
| SCHEMBL670216 | 0.83 | PTK2 (0.65) | PTK2PTK2BJAK2JAK3PLK4 | |
| SCHEMBL669191 | 0.78 | PTK2 (0.43) | PTK2PTK2BJAK2JAK3AURKA | |
| SCHEMBL669471 | 0.77 | PTK2 (0.76) | PTK2PTK2BJAK2JAK3PLK4 | |
| SCHEMBL670218 | 0.74 | PTK2 (0.56) | PTK2PTK2BJAK2JAK3 | |
| SCHEMBL670057 | 0.72 | PTK2 (0.54) | PTK2PTK2BJAK2JAK3PLK4 | |
| SCHEMBL668640 | 0.72 | PTK2 (0.47) | PTK2PTK2BJAK2JAK3 | |
| SCHEMBL10125444 | 0.72 | PTK2 (0.48) | PTK2PTK2BSRPK1 | |
| SCHEMBL670377 | 0.72 | PTK2 (0.62) | PTK2PTK2BJAK2JAK3SRPK1 | |
| SCHEMBL10125484 | 0.71 | PTK2 (0.64) | PTK2PTK2BJAK2JAK3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | claimed |
| EP-2606034-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | Merck Patent GmbH (DE) | 2013-06-26 | — | — | EP | claimed |
| WO-2012022408-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | WO | claimed |
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |