Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.68 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.49 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439134 | 0.86 | ESR2 (0.66) | SIRT2SIRT1ESR1ESR2HSD17B10 | |
| SCHEMBL541343 | 0.83 | HSD17B10 (0.76) | SIRT2SIRT1HSD17B10FGFR1HPGD | |
| SCHEMBL6789587 | 0.82 | SIRT2 (0.47) | SIRT2SIRT1ESR1ESR2HSD17B10 | |
| SCHEMBL5579900 | 0.81 | ESR1 (0.68) | SIRT2SIRT1ESR1ESR2HSD17B10 | |
| SCHEMBL12089843 | 0.80 | FGFR1 (0.58) | SIRT2SIRT1HSD17B10FGFR1HPGD | |
| SCHEMBL26931778 | 0.78 | SIRT2 (0.60) | SIRT2SIRT1PTGER4HPGDKDM4E | |
| SCHEMBL29829285 | 0.78 | SIRT2 (0.60) | SIRT2SIRT1PTGER4HPGDKDM4E | |
| SCHEMBL5065691 | 0.77 | RPS6KB1 (0.61) | PTGER4KDM4EALOX15ALDH1A1ATM | |
| SCHEMBL8023395 | 0.77 | SIRT2 (0.61) | SIRT2SIRT1HSD17B10FGFR1PTGER4 | |
| SCHEMBL422989 | 0.76 | ALDH1A1 (0.50) | SIRT2SIRT1ESR1ESR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429759-A4 | COMPOUNDS USEFUL FOR TREATING HEPATITUS C VIRUS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1429759-A2 | COMPOUNDS USEFUL FOR TREATING HEPATITUS C VIRUS | Bristol-Myers Squibb Company (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003026587-A2 | COMPOUNDS USEFUL FOR TREATING HEPATITUS C VIRUS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-04-03 | — | — | WO | disclosed |