Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 7/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28671758 | 0.87 | SLC7A5 (0.44) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL27496931 | 0.87 | SLC7A5 (0.46) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL6005504 | 0.87 | SLC7A5 (0.46) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL28977983 | 0.87 | SLC7A5 (0.46) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL28335300 | 0.86 | SLC7A5 (0.41) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL27759487 | 0.86 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL3050307 | 0.86 | SLC7A5 (0.49) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL3050310 | 0.86 | SLC7A5 (0.49) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL29670800 | 0.86 | SLC7A5 (0.45) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 | |
| Histidine SCHEMBL28093403 | 0.86 | SLC7A5 (0.45) | SLC7A5CYP3A4CYP1A2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118165952-A | Thermostable methyltransferase and application thereof | 上海光玥生物科技有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-118125980-A | Method for separating and purifying histidine betaine | 珠海宝锐生物科技有限公司 | 2024-06-04 | — | — | CN | claimed |
| CN-117721056-B | Genetically engineered bacterium and application thereof in production of ergothioneine | 广州同隽医药科技有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-118086420-A | Synthesis method of ergothioneine | 珠海宝锐生物科技有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-117736957-B | Genetically engineered bacterium for producing ergothioneine and application thereof in producing ergothioneine | 广州同隽医药科技有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-117083377-B | Chemo-enzyme coupling method for synthesizing ergothioneine | 中国科学院上海有机化学研究所 | 2024-04-26 | — | — | CN | claimed |
| CN-117736957-A | Genetically engineered bacterium for high-yield ergothioneine and application thereof in production of ergothioneine | 广州同隽医药科技有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117721056-A | Genetically engineered bacterium and application thereof in production of ergothioneine | 广州同隽医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-117603923-A | Mononuclear non-heme iron enzyme, gene, expression vector, strain and application thereof | 上海光玥生物科技有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-117083377-A | Chemo-enzyme coupling method for synthesizing ergothioneine | 中国科学院上海有机化学研究所 | 2023-11-17 | — | — | CN | claimed |
| US-5972840-A | Osmolyte regulator | AB TALL (HOLDINGS) PTY. LTD. (AU) | 1999-10-26 | — | — | US | claimed |
| EP-0806897-A4 | OSMOLYTE REGULATOR | TALL HOLDINGS PTY LTD AB (AU) | 1999-06-16 | — | — | EP | claimed |
| WO-1999004784-A1 | A PROPHYLACTIC | CULTOR CORPORATION (FI) | 1999-02-04 | — | — | WO | claimed |
| EP-0790772-A4 | OSMOLYTE REGULATOR | TALL HOLDINGS PTY LTD AB (AU) | 1999-01-27 | — | — | EP | claimed |
| WO-1998046074-A1 | IMPROVING THE PRESERVABILITY OF PLANTS | CULTOR CORPORATION (FI) | 1998-10-22 | — | — | WO | claimed |
| WO-1998037763-A1 | PEST RESISTANCE ENHANCEMENT METHOD | AB TALL (HOLDINGS) PTY. LTD. (AU) | 1998-09-03 | — | — | WO | claimed |
| EP-0806897-A1 | OSMOLYTE REGULATOR | A.B. TALL (HOLDINGS) PTY LTD. (AU) | 1997-11-19 | — | — | EP | claimed |
| EP-0790772-A1 | OSMOLYTE REGULATOR | A.B. TALL (HOLDINGS) PTY LTD. (AU) | 1997-08-27 | — | — | EP | claimed |
| WO-1996023413-A1 | OSMOLYTE REGULATOR | AB TALL (HOLDINGS) PTY. LTD. (AU) | 1996-08-08 | — | — | WO | claimed |
| WO-1996014749-A1 | OSMOLYTE REGULATOR | AB TALL (HOLDINGS) PTY. LTD. (AU) | 1996-05-23 | — | — | WO | claimed |