Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700580 | 0.88 | HPGD (0.44) | HPGDHDAC3HDAC1HDAC2MAPT | |
| SCHEMBL6700774 | 0.88 | HPGD (0.46) | HPGDHDAC3HDAC1HDAC2MAPT | |
| SCHEMBL6701630 | 0.74 | HPGD (0.41) | HPGDMAPTALDH1A1TSHRKMT2A | |
| SCHEMBL13127007 | 0.65 | NPC1 (0.56) | LMNASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL6359381 | 0.65 | HDAC3 (0.71) | HPGDSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL8544861 | 0.64 | SMPD1 (0.53) | TP53MDM2THRBHPGDSMN1; SMN2 | |
| SCHEMBL10585478 | 0.63 | CNR1 (0.69) | LMNASMN1; SMN2HDAC1HDAC2MAPT | |
| SCHEMBL20772601 | 0.62 | TP53 (0.47) | TP53MDM2HPGDLMNASMN1; SMN2 | |
| SCHEMBL712405 | 0.62 | MAPK1 (0.46) | THRBKCNA5KCNH2HPGDLMNA | |
| SCHEMBL13719645 | 0.61 | POLB (0.65) | TP53THRBLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102488-A1 | Butenolide and pentenolide derivatives as kinase inhibitors | MORPHOCHEM AG (DE) | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102488-A1 | Butenolide and pentenolide derivatives as kinase inhibitors | MAP3K20, MAP3K21, MAP3K1 | TP53 2243/4885MDM2 4040/4885THRB 1549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.