Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | PDE6C | P51160 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450300 | 0.87 | PDE5A (0.41) | PDE5AHDAC6HDAC1HDAC2PDE6C | |
| SCHEMBL5078828 | 0.82 | PDE5A (0.33) | PDE5AHDAC6HDAC1HDAC2PDE6C | |
| SCHEMBL15111167 | 0.77 | PDE5A (0.49) | PDE5AHDAC6HDAC1HDAC2PDE6C | |
| SCHEMBL5201813 | 0.73 | NPSR1 (0.41) | PDE5APDE6CKMT2AHPGD | |
| SCHEMBL3453681 | 0.73 | PDE5A (0.53) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL1913406 | 0.71 | PDE5A (0.55) | PDE5APDE6CKMT2AMEN1ALDH1A1 | |
| SCHEMBL7450974 | 0.71 | PDE5A (0.45) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL7368938 | 0.71 | KMT2A (0.30) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL7449440 | 0.70 | PDE5A (0.56) | PDE5AHDAC6HDAC1HDAC2PDE6C | |
| SCHEMBL6249380 | 0.68 | PDE5A (0.42) | PDE5AHDAC6HDAC1HDAC2PDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024419-A2 | BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA | ALCON RESEARCH, LTD. (US) | 2012-02-23 | — | — | WO | disclosed |
| EP-1418896-A2 | ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF PREMATURE EJACULATION | Vivus, Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003000343-A2 | ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF PREMATURE EJACULATION | VIVUS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |