Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361790 | 0.79 | — | — | |
| SCHEMBL5201813 | 0.73 | NPSR1 (0.41) | KMT2APDE5AHPGD | |
| SCHEMBL3453681 | 0.73 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5078828 | 0.73 | PDE5A (0.33) | KMT2AMEN1PDE5AALDH1A1HPGD | |
| SCHEMBL1913406 | 0.69 | PDE5A (0.55) | KMT2AMEN1PDE5AALDH1A1HPGD | |
| SCHEMBL7449440 | 0.68 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7428886 | 0.62 | PDE5A (0.68) | KMT2AMEN1PDE5AALDH1A1HPGD | |
| SCHEMBL7359421 | 0.61 | PDE5A (0.42) | PDE5AALDH1A1PDE1APDE1BPDE1C | |
| SCHEMBL23615906 | 0.58 | KMT2A (0.46) | KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL7360293 | 0.58 | ALDH1A1 (0.39) | KMT2AMEN1PDE5AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001003644-A2 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2001-01-18 | — | — | WO | disclosed |