Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.41 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6402640 | 0.93 | OPRL1 (0.41) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6394809 | 0.92 | OPRL1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6396515 | 0.91 | OPRL1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6402947 | 0.91 | OPRL1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6395825 | 0.90 | OPRL1 (0.43) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6402055 | 0.90 | OPRL1 (0.41) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6429456 | 0.89 | OPRL1 (0.45) | OPRL1OPRM1OPRK1 | |
| Citric Acid SCHEMBL6393549 | 0.89 | OPRL1 (0.41) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL6396207 | 0.89 | OPRL1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 | |
| Citric Acid SCHEMBL7069932 | 0.89 | OPRL1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |