Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.42 |
| ▸ | HTR7 known ✓ | P34969 | 2/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7069932 | 1.00 | OPRL1 (0.42) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| Citric Acid SCHEMBL6396515 | 0.93 | OPRL1 (0.42) | OPRL1OPRM1SIGMAR1SLC18A3OPRK1 | |
| Citric Acid SCHEMBL6402947 | 0.93 | OPRL1 (0.42) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| Citric Acid SCHEMBL6395825 | 0.92 | OPRL1 (0.43) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| SCHEMBL6397610 | 0.92 | OPRL1 (0.47) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| SCHEMBL6397606 | 0.92 | OPRL1 (0.47) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6396517 | 0.91 | OPRL1 (0.46) | OPRL1OPRM1HTR1AHTR7SIGMAR1 | |
| Citric Acid SCHEMBL6394809 | 0.91 | OPRL1 (0.42) | OPRL1OPRM1SIGMAR1SLC18A3OPRK1 | |
| Citric Acid SCHEMBL6402640 | 0.90 | OPRL1 (0.41) | OPRL1OPRM1SIGMAR1SLC18A3OPRK1 | |
| Citric Acid SCHEMBL6703771 | 0.89 | OPRL1 (0.41) | OPRL1OPRM1SIGMAR1SLC18A3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038060-A1 | Spiropoperidine compounds as ligands for orl-1 receptor | ANDO KOJI (JP) | 2005-02-17 | — | — | US | disclosed |
| US-20030078279-A1 | Spiropiperidine compounds as ligands for ORL-1receptor | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| US-20030078278-A1 | Spiropiperidine compounds as ligands for ORL-1 receptor | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078278-A1 | Spiropiperidine compounds as ligands for ORL-1 receptor | OPRL1, OPRD1, OXER1 | OPRM1 10/4885HTR7 1608/4885SIGMAR1 9/4885 |
| US-20030078279-A1 | Spiropiperidine compounds as ligands for ORL-1receptor | OPRL1, OPRD1, OXER1 | OPRM1 11/4885HTR7 1552/4885SIGMAR1 13/4885 |
| US-20050038060-A1 | Spiropoperidine compounds as ligands for orl-1 receptor | OPRL1, OXER1, OGFRL1 | OPRM1 14/4885HTR7 2187/4885SIGMAR1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.