Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000683 | 0.86 | ACHE (0.50) | HRH1CYP19A1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL3910832 | 0.85 | TAAR1 (0.64) | HRH1HTR2ACYP19A1ACP3TAAR1 | |
| SCHEMBL6546957 | 0.83 | CYP19A1 (0.51) | HRH1HTR2ACYP19A1LMNAMAPT | |
| SCHEMBL158098 | 0.82 | HRH1 (1.00) | HRH1HTR2ALMNAALOX12HTT | |
| SCHEMBL27466804 | 0.81 | CYP19A1 (0.50) | HRH1HTR2ACYP19A1LMNAMAPT | |
| SCHEMBL20274525 | 0.81 | TAAR1 (0.47) | HRH1HTR2ACYP19A1ACP3TAAR1 | |
| SCHEMBL4381016 | 0.80 | TAAR1 (0.56) | HTR2ACYP19A1MAPTACP3TAAR1 | |
| SCHEMBL6546797 | 0.80 | CYP19A1 (0.56) | HRH1HTR2ACYP19A1LMNAMAPT | |
| Ammonia Solution, Strong SCHEMBL3795841 | 0.80 | HRH1 (0.95) | HRH1HTR2ALMNAALOX12HTT | |
| Iodide SCHEMBL28361744 | 0.80 | HRH1 (0.95) | HRH1HTR2ALMNAALOX12HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1088585-C | Compound active at a novel site on receptor-operated calcium channels usefull for treatment of neurological disorders and diseases | NPS PHARMACEUTICAL CO LTD (US) | 2002-08-07 | — | — | CN | claimed |
| EP-0743853-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMA INC (US) | 2001-05-02 | — | — | EP | claimed |
| EP-2855421-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 3,3-DIPHENYLPROPYLAMINES | CRYSTAL PHARMA SAU (ES) | 2018-03-21 | — | — | EP | disclosed |
| JP-2004002437-A | COMPOUND ACTIVE AT NEW POSITION ON RECEPTOR-OPERATED CALCIUM CHANNEL USEFUL FOR TREATING NEUROPRAXIA AND NEUROPATHY | NPS PHARMACEUT INC | 2004-01-08 | — | — | JP | disclosed |
| EP-0743853-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMA INC (US) | 2001-05-02 | — | — | EP | disclosed |